Lethality Vayne Build

Lethality Vayne build with runes and items. Lethality Vayne guide offers in-depth how-to play, skill order and tips. Play Lethality Vayne build in League of Legends Patch 14.12!

Updated: 2024-06-17 ()
ARAM Build Guide for champion Vayne and build Lethality.
Vayne Lethality build for ARAM with tons of AD and Lethality.
Vayne ARAM modifiers
DMG done +5%
DMG taken -5%

TLDR

Starting items
Long Sword should be final item in your build.
Tear of the Goddess should be final item in your build.
Long Sword should be final item in your build.
Quick Skill Order
Vayne ability Tumble should be leveled first.
Q
Vayne ability Silver Bolts should be leveled second.
W
Vayne ability Condemn should be leveled third.
E
Final items
Ionian Boots of Lucidity should be final item in your build.
The Collector should be final item in your build.
Muramana should be final item in your build.
Opportunity should be final item in your build.
Serylda's Grudge should be final item in your build.
Hubris should be final item in your build.
Quick Runes
Major rune Dark Harvest from Domination tree.
Minor rune Precision.
Summoner spells
Pick Ghost as your Summoner Spell.
Pick Flash as your Summoner Spell.

Lethality Vayne Runes

Domination
Domination major tree Electrocute rune.
Domination major tree Dark Harvest rune.
Domination major tree Hail of Blades rune.
Domination major tree Cheap Shot rune.
Domination major tree Taste of Blood rune.
Domination major tree Sudden Impact rune.
Domination major tree Zombie Ward rune.
Domination major tree Ghost Poro rune.
Domination major tree Eyeball Collection rune.
Domination major tree Treasure Hunter rune.
Domination major tree Relentless Hunter rune.
Domination major tree Ultimate Hunter rune.
Precision
Precision minor tree Absorb Life rune.
Precision minor tree Triumph rune.
Precision minor tree Presence of Mind rune.
Precision minor tree Legend: Alacrity rune.
Precision minor tree Legend: Haste rune.
Precision minor tree Legend: Bloodline rune.
Precision minor tree Coup de Grace rune.
Precision minor tree Cut Down rune.
Precision minor tree Last Stand rune.
Passive
Passive tree Adaptive Force rune (+9 Adaptive Force).
Passive tree Attack Speed rune (+10% Attack Speed).
Passive tree Ability Haste rune (+8 Ability Haste).
Passive tree Adaptive Force rune (+9 Adaptive Force).
Passive tree Move Speed rune (+2 Movement Speed).
Passive tree Health Scaling rune (+10-180 Health (based on level)).
Passive tree Health rune (+65 Health).
Passive tree Tenacity And Slow Resist rune (+10 Tenacity and Slow Resist).
Passive tree Health Scaling rune (+10-180 Health (based on level)).

How to play

  1. You build Lethality and play like AD caster.
  2. If an enemy team is full of tanks or bruisers, rush Serylda's Grudge or even Lord Dominik's Regards early (sometimes even #2). Black Cleaver is also an alternative. The key is to adapt to the enemy team.
  3. Play like AD caster. Casting Q will be your main source of damage.

Tips and Tricks

Riot
  1. Tumble has many uses, but it cannot pass over walls.
  2. Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
  3. Don't go in first to a large teamfight. Wait for your teammates to initiate.

Skill Order

  • Vayne [object Object] ability.
    Q
    Tumble
  • Vayne [object Object] ability.
    W
    Silver Bolts
  • Vayne [object Object] ability.
    E
    Condemn
  • Vayne [object Object] ability.
    R
    Final Hour

Items

Starting items
Long Sword item.
Tear of the Goddess item.
Long Sword item.
Rush this
The Collector item.
Boots
Ionian Boots of Lucidity item.
Mercury's Treads item.
Plated Steelcaps item.
Berserker's Greaves item.
Get it post 15 lvl
Zephyr item.
Good items
The Collector item.
Spear of Shojin item.
Essence Reaver item.
Voltaic Cyclosword item.
Opportunity item.
Youmuu's Ghostblade item.
Serylda's Grudge item.
OK items
Umbral Glaive item.
Edge of Night item.
Essence Reaver item.
Axiom Arc item.
For mana problems
Tear of the Goddess item.
Muramana item.
Counter items
Additional considerations for these items is advised!
Chempunk Chainsword item.
Serpent's Fang item.
Executioner's Calling item.
Mercurial Scimitar item.
Anti tank items
Additional considerations for these items is advised!
Blade of The Ruined King item.
Lord Dominik's Regards item.
Black Cleaver item.
Good defensive items
Maw of Malmortius item.
Death's Dance item.
Anti poke items
Kaenic Rookern item.
Warmog's Armor item.
For the last fight
Additional considerations for these items is advised!
Elixir of Iron item.
Elixir of Wrath item.
Example final build
Ionian Boots of Lucidity item.
The Collector item.
Muramana item.
Opportunity item.
Serylda's Grudge item.
Hubris item.